Slow release morphine
نویسندگان
چکیده
منابع مشابه
Effect of filtration on morphine and particle content of injections prepared from slow-release oral morphine tablets
BACKGROUND Injections of mixtures prepared from crushed tablets contain insoluble particles which can cause embolisms and other complications. Although many particles can be removed by filtration, many injecting drug users do not filter due to availability, cost or performance of filters, and also due to concerns that some of the dose will be lost. METHODS Injection solutions were prepared fr...
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The objectives of this study were to evaluate poloxamer as a slow release carrier for morphine (M) and potential tissue irritation after subcutaneous poloxamer-morphine (PM) injection in a rat model. Based on the result of a previous in vitro work, 25% poloxamer, with and without morphine, and saline were administered in 14 rats' flanks. Blood for morphine concentrations was automatically sampl...
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In a double-blind cross-over study, the effects of slow release (S-R) terbutaline tablets (b.i.d. 0.25 mg/kg per day) and S-R theophylline (5.31 mg/kg morning and 10.62 mg/kg evening) were compared in eleven patients with nocturnal asthma. On day seven of each treatment period, drug serum concentrations and peak expiratory flow (PEF) were measured every 2h over a 24-h period. During daytime, te...
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Sustained-release oral morphine sulphate (MST) 20 mg was administered to 11 healthy volunteers. Mean peak plasma morphine concentration was 14.8 ng ml-1, and occurred at a mean time of 142.5 min after ingestion. Analgesia assessed by an ischaemic forearm pain test increased to a maximum approximately 40 min after the calculated peak plasma concentration of morphine had been achieved, and remain...
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-brain levels of HCP varied between 0-442 and 1-204 nmol[g (0-18 and 0 49 ig/g).4 So myelinopathy in case 2 was probably attributable to HCP, despite the absence of clinical signs of toxicity. The trace level in case 1 suggests that myelinopathy was unrelated to HCP, for other causes of infantile spongioform myelinopathy are known, though none has been identified in small premature infants. Nev...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1985
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1985.tb10624.x